Like James A. Garfield, an earlier U.S. president from Ohio, Harding conducted his election campaign mainly from the house's expansive front porch. During the three-month front porch campaign, over 600,000 people traveled to the Harding Home to listen to Warren speak. Harding paid $1,000 dollars to have a Sears catalog house built behind his home so newspaper reporters had workspace to type their stories. George Christian (Warren's next door neighbor and Press Secretary) allowed his home to be used as Republican Headquarters for the campaign.

The house is surrounded by an expansive, elaborately detailed porch. Entry to the house is through a reception hall, with a parlor on the left. A dining room and Harding's office are also in the first floor. There are four bedrooms on the second floor and a bathroom. Built-in closets are an unusual feature for the time.

Mrs. Harding bequeathed the house to the Harding Memorial Association. The Ohio Historical Society now operates the home as a historic house museum and a memorial. The restored house contains almost all original furnishings owned by President Harding and his wife. The adjacent press house features exhibits about the lives of President and Mrs. Harding. The collection at the Harding Home is over 5,000 original artifacts that belonged to Warren and Florence Harding.