Isabel's line goes back to Charlemagne per https://threefamilytrees.blogspot.com/2018/.

Historical
1324: Mali, Saudi Arabia - Ruler of Mali makes pilgrimage to Mecca
1326: France, England - England is Invaded by the French wife of King Edward II, Isabelle, she is supported by French troops and gains control of England as Edward II was forced to flee London, Isabelle arranges for her son Edward III to be crowned King of England
1326: Turkey - Ottoman Empire is established when the Byzantine fortress of Bursa fall after a nine-year siege to the forces of the Osmali Turks, under Osman who soon dies and is succeeded by his son Orkhan who rules until 1360
1337: England, France - Hundred Years War begins when French king Philip VI contests the English claim to Normandy and other northern provinces while at the same time, English king Edward III contests the legitimacy of Philip based on the fact that his mother was the daughter of Philip IV and demands the crown of France
1340: England, France - Battle Of Crecy, British forces under command Edward III defeat a French army commanded by Philip VI, It is the first use of cannon and small arms in a Eropean battle
1340: England, France - Battle of Sluis (off the coast of Flanders), the English navy destroys the French navy giving the English naval supremacy in the English Channel
1346: England, France - Edward III of England defeats Philip VI of France at Crecy en Ponthieu, English longbowmen so far eclipse Genoese crossbowmen that the long bow replaces the cross bow as an Instrument of war
1347-1353: Europe - The Black Death (aka. bubonic plague) spreads throughout Europe, It is the worse natural disaster in European history, an estimated 19 to 35 million die, the plague is spread by rats Infested by Infected fleas, the plague originated in the East and ships carrying Infected vermin came to the Island of Sicily then spread northward, a bizarre effect of the plague was the large-scale outbreak of anti-semitism from the belief that the Jews caused the plague
1348: Poland - Casimir III the King of Poland starts the University Of Kracow