Historical
1520-1566: Turkey - The reign of Suleiman the Magnificent marks the zenith of the Ottoman Empire
1520: Portugal, Ethiopia - The first European diplomatic mission to Ethiopia, sent by the Portuguese, arrives at Massawa 9 April, and reaches the Imperial encampment of Emperor Dawit II in Shewa 9 October
1521: Philippines - Philippines discovered by Ferdinand Magellan, he was later killed in battle in central Philippines in the same year
1521: Portugal, China - After building fortifications at Tuen Mun, the Portuguese attempt to Invade Ming Dynasty China, but are expelled by Chinese naval forces
1521: Turkey, Serbia - Belgrade is captured by the Ottoman Empire
1522: Turkey - Rhodes falls to the Ottoman Turks of Suleiman the Magnificent, the tenth and longest-reigning Sultan of the Ottoman Empire
1523: Sweden, Norway, Denmark - Sweden gains Independence from the Kalmar Union
1524-1525: Germany - German Peasants War in the Holy Roman Empire
1524: North America - Giovanni da Verrazzano is the first European to explore the Atlantic coast of North America between South Carolina and Newfoundland
1525: Spain, german, France - Battle of Pavia, Spain and Germany defeat Francis I of France and capture him
1526: India - Mughal Empire, founded by Babur, rules India until 1739 and hold titles until 1857
1526: Turkey. Hungary - Battle of Mohacs, the Ottomans defeat the Kingdom of Hungary
1527: Italy - Charles V, Holy Roman Emperor, sacks Rome, this basically ends the Italian Renaissance
1527: Sweden - Protestant Reformation begins in Sweden
1529: Austria, Turkey - Siege of Vienna, Austrians defeat the Ottoman Empire
1529: Ethiopia - Battle of Shimbra, Kure Imam Ahmad Gragn defeats the Ethiopian Emperor Dawit II, the opening clash of the Ethiopian-Adal War
1529: Portugal, Spain - Treaty of Zaragoza defined the antimeridian of Tordesillas attributing the Moluccas to Portugal and Philippines to Spain
1531-1532: England - The Church of England breaks away from the Roman Catholic Church and recognizes King Henry VIII as the head of the Church
1531: Peru - The Inca Civil War is fought between the two brothers, Atahualpa and Huascar
1532: Spain, Peru - Francisco Pizarro leads the Spanish conquest of the Inca Empire
1533: England - Anne Boleyn becomes Queen of England
1533: England - Elizabeth Tudor is born
1534: France, Canada - Jacques Cartier claims Quebec for France
1534: France - Affair of the Placards, Francis becomes more active in repression of French Protestants
1534: Turkey, Iraq - Battle of Baghdad, Ottomans capture Baghdad
1535: Germany - The Munster Rebellion, an attempt of radical, millennialist, Anabaptists in Germany to establish a theocracy ends in bloodshed
1536: Argentina - Foundation of Buenos Aires by Pedro de Mendoza
1536: England - Anne Boleyn is beheaded for adultery and treason
1536: Portugal - Establishment of the Inquisition in Portugal
1537: Portugal, Brazil - Portuguese establishes Recife in Pernambuco, north-east of Brazil
1538: Turkey, Spain, Italy - Battle of Preveza, Ottoman Turks defeat the Spanish-Venetian fleet
1539: North America - Hernando de Soto explores Inland North America
1541: Algeria, Spain - An Algerian military campaign by Charles V of Spain (Habsburg) is unsuccessful
1541: Brazil - Amazon River is discovered and explored by Francisco de Orellana
1541: Chile - Pedro de Valdivia founds Santiago de Chile
1541: Korea, Russia - Sahib I Giray of Crimea Invade Russia
1541: Turkey, Hungary - Capture of Buda and the absorption of the major part of Hungary by the Ottoman Empire
1542: France, England, Scotland - War resumes between Francis I of France and Emperor Charles V, this time Henry VIII is allied to the Emperor, while James V of Scotland and Sultan Suleiman I are allied to the French
1543: Ethiopia, Portugal - Battle of Wayna Daga, Ethiopian/Portuguese troops decisively defeat the Muslim army, Imam Ahmad Gragn killed
1543: Portugal, Japan - The Nanban trade period begins after Portuguese traders make contact with Japan
1544: France, Spain - Battle of Ceresole, French defeat an Imperial-Spanish army
1544: Scotland - Battle of the Shirts in Scotland, the Frasers and Macdonalds of Clan Ranald fight over a disputed chiefship, reportedly, 5 Frasers and 8 Macdonalds survive
1546: Italy - Michelangelo Buonarroti is made chief architect of St. Peters Basilica
1547: Russia - Grand Prince Ivan the Terrible is crowned tsar of (All)Russia, thenceforth becoming the first Russian tsar
1547: Spain, Italy, Hungary - Battle of Muhlberg, Emperor Charles V decisively dismantles the Schmalkaldic League
1548: China, Japan - The Ming Dynasty government of China Issues a decree banning all foreign trade and closes down all seaports along the coast, these Hai jin laws came during the Wokou wars with Japanese pirates
1548: Japan - Battle of Uedahara, firearms are used for the first time on the battlefield in Japan, and Takeda Shingen is defeated by Murakami Yoshikiyo
1549: El Salvador, Brazil - Tome de Souza establishes Salvador in Bahia, northeast of Brazil
1550-1551: Spain, Americas - Valladolid debate concerning the existence of souls in AmerIndians
1550: Mongolia, China - Mongols led by Altan Khan Invade China and besiege Beijing
1551: England - Fifth outbreak of sweating sickness in England, John Caius of Shrewsbury writes the first full contemporary account of the symptoms of the disease
1551: Malta, Libya - North African pirates enslave the entire population of the Maltese Island Gozo, between 5,000 and 6,000, sending them to Libya
1552: Russia, Bulgaria - Russia conquers the Khanate of Kazan
1553: England - Mary Tudor becomes the first queen regnant of England
1554: Brazil - Portuguese missionaries Jose de Anchieta and Manuel da Nobrega establishes Sao Paulo, southeast Brazil
1555: England, Russia - The Muscovy Company is the first major English joint stock trading company
1556-1605: India - During his reign, Akbar expands the Mughal Empire in a series of conquests
1556: China - The Shaanxi Earthquake in China is the deadliest known earthquake in history
1556: Germany - Georgius Agricola of Germany, the "Father of Mineralogy", publishes his De re metallica
1556: India - Mir Chakar Khan Rind captured Delhi with Emperor Humayun
1556: India - Second Battle of Panipat, Akbar the Great defeats the Sultan of Bengal
1556: Italy - Pomponio Algerio, radical theologian, is executed by boiling in oil as part of the Roman Inquisition
1556: Italy - Publication in Venice of Delle Navigiationi et Viaggi (terzo volume) by Giovanni Battista Ramusio, secretary of Council of Ten, with plan La Terra de Hochelaga, an Illustration of Indian village Hochelaga
1556: Russia - Russia conquers the Astrakhan Khanate
1557: Portugal, China - The Portuguese settle in Macau in China
1557: Spain - Spain became the first sovereign nation in history to declare bankruptcy, Philip II of Spain had to declare four state bankruptcies in 1557, 1560, 1575 and 1596
1557: Turkey, Ethiopia - The Ottomans capture Massawa, all but Isolating Ethiopia from the rest of the world
1558-1583: Poland, Lithuania, Sweden, Denmark, Russia - Livonian War between Poland, Grand Principality of Lithuania, Sweden, Denmark and Russia
1558-1603: England - The Elizabethan era is considered the height of the English Renaissance
1558: England, France - After 200 years, the Kingdom of England loses Calais to France
1558: England - Elizabeth Tudor becomes Queen Elizabeth I at age 25
1559: Italy - With the Peace of Cateau Cambresis, the Italian Wars conclude
1560: Hungary - Erzsebet Bathory is born in Nyirbator, Hungary
1560: Japan - By winning the Battle of Okehazama, Oda Nobunaga becomes one of the pre-eminent warlords of Japan
1560: Turkey, Spain - Battle of Djerba, Ottoman navy defeats the Spanish fleet
1561: western Europe - Guido de Bres draws up the Belgic Confession of Protestant faith
1562-1598: France - French Wars of Religion between Catholics and Huguenots
1562: France - Massacre of Wassy and Battle of Dreux in the French Wars of Religion
1562: India - Mughal leader Akbar reconciles the Muslim and Hindu factions by marrying into the powerful Rajput Hindu caste
1563: England - Plague outbreak claimed 80,000 people in Elizabethan England, in London alone, over 20,000 people died of the disease
1564: England - William Shakespeare baptized 26 April
1564: Italy - Galileo Galilei born on February 15
1565: Bazil - Estacio de Sa establishes Rio de Janeiro in Brazil
1565: India - Battle of Talikota fought between the Hindu kingdom of Vijayanagar and the Deccan sultanates
1565: Israel, Turkey - Siege of Malta, Hospitallers defeat the Ottoman Empire
1565: Pakistan - Mir Chakar Khan Rind dies at age of 97
1566–1648:: Spain, Netherlands - Eighty Years War between Spain and the Netherlands
1567: England, Scotland - Mary, Queen of Scots, is Imprisoned by Elizabeth I
1568-1570: Russia, Turkey - Russo-Turkish War (first of ten over the next 310 years), Russian victory, they were victorious in eight of the ten wars
1568-1571: Spain - Morisco Revolt in Spain
1568-1600: Japan - The Azuchi-Momoyama period in Japan
1569: England - Rising of the North in England, also called the Revolt of the Northern Earls, and, Northern Rebellion, It is an unsuccessful attempt by Catholic noblemen from northern England to depose Queen Elizabeth I of England and replace her with Mary, Queen of Scots
1569: Poland, Lithuiana - The Polish-Lithuanian Commonwealth is created with the Union of Lublin, It lasts until 1795
1570: Russia - Ivan IV Vasilyevich (Ivan the Terrible) orders the massacre of Inhabitants of Novgorod